EI-1941-1 and -2, novel interleukin-1 beta converting enzyme inhibitors Produced by Farrowia sp. E-1941. II. Taxonomy of producing strain, fermentation, isolation, physico-chemical properties, and biological properties.

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ID: 1081
2003
EI-1941-1 and -2, novel interleukin-1 beta converting enzyme (ICE) inhibitors, were isolated from the culture broths of Farrowia sp. E-1941. EI-1941-1 and -2 selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006 microM, respectively. Taxonomy and fermentation of the producing strain and isolation, physico-chemical properties, structure elucidation, and biological properties of EI-1941-1 and -2 are described.
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Authors Koizumi, Fumito;Ishiguro, Hiroki;Ando, Katsuhiko;Kondo, Hidemasa;Yoshida, Mayumi;Matsuda, Yuzuru;Nakanishi, Satoshi;
Journal the journal of antibiotics
Year 2003
DOI DOI not found
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