Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade

Clicks: 683
ID: 113731
2011
The peroxiredoxin (PRX) family of antioxidant enzymes helps maintain the intracellular reducing milieu and suppresses apoptosis in non-neuronal cells. However, whether PRX can inhibit neuronal apoptosis through specific signaling mechanisms remains poorly understood. Induction of PRX2, the most abun …
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Authors Hu X;Weng Z;Chu CT;Zhang L;Cao G;Gao Y;Signore A;Zhu J;Hastings T;Greenamyre JT;Chen J;;
Journal The Journal of neuroscience : the official journal of the Society for Neuroscience
Year 2011
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/21209210
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male N.I.H. Extramural Disease Models Animal aged middle aged 80 and over cell line Cell Differentiation / drug effects gene expression regulation / drug effects enzyme inhibitors / pharmacology brain / drug effects brain / metabolism analysis of variance signal transduction / drug effects* cell survival / drug effects gene expression regulation / genetics pmid:21209210 pmc3078571 doi:10.1523/jneurosci.4589-10.2011 xiaoming hu zhongfang weng jun chen apomorphine brain / pathology cytochromes / pharmacology dopamine / metabolism* green fluorescent proteins / genetics indoles map kinase kinase kinase 5 / drug effects* motor activity / drug effects neurodegenerative diseases / chemically induced neurodegenerative diseases / prevention & control* neuroprostanes / therapeutic use* oxidopamine / adverse effects parkinson disease / metabolism parkinson disease / pathology peroxiredoxins / therapeutic use* postmortem changes small interfering / metabolism thioredoxins / pharmacology

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