Genome sequencing in microfabricated high-density picolitre reactors
Clicks: 268
ID: 114584
2005
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophores …
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m2005naturegenome
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| Authors | Margulies M;Egholm M;Altman WE;Attiya S;Bader JS;Bemben LA;Berka J;Braverman MS;Chen YJ;Chen Z;Dewell SB;Du L;Fierro JM;Gomes XV;Godwin BC;He W;Helgesen S;Ho CH;Irzyk GP;Jando SC;Alenquer ML;Jarvie TP;Jirage KB;Kim JB;Knight JR;Lanza JR;Leamon JH;Lefkowitz SM;Lei M;Li J;Lohman KL;Lu H;Makhijani VB;McDade KE;McKenna MP;Myers EW;Nickerson E;Nobile JR;Plant R;Puc BP;Ronan MT;Roth GT;Sarkis GJ;Simons JF;Simpson JW;Srinivasan M;Tartaro KR;Tomasz A;Vogt KA;Volkmer GA;Wang SH;Wang Y;Weiner MP;Yu P;Begley RF;Rothberg JM;; |
| Journal | Nature |
| Year | 2005 |
| DOI | DOI not found |
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
reproducibility of results
research support
u.s. gov't
N.I.H.
Extramural
P.H.S.
Sequence Analysis
genome
polymerase chain reaction
sensitivity and specificity
bacterial*
time factors
electrophoresis
genomics / instrumentation*
pmid:16056220
pmc1464427
doi:10.1038/nature03959
marcel margulies
michael egholm
jonathan m rothberg
capillary
emulsions
fiber optic technology
genomics / economics
microchemistry / economics
microchemistry / instrumentation*
mycoplasma genitalium / genetics*
dna / economics
dna / instrumentation*
|
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