Stunting Is Characterized by Chronic Inflammation in Zimbabwean Infants
Clicks: 298
ID: 115929
2014
Background Stunting affects one-third of children in developing countries, but the causes remain unclear. We hypothesized that enteropathy leads to low-grade inflammation, which suppresses the growth hormone-IGF axis and mediates stunting. Methods We conducted a case-control study of 202 HIV-unexposed Zimbabwean infants who were stunted (height-for-age Z-score (HAZ) −0.5; controls) at 18 months. We measured biomarkers of intestinal damage (I-FABP), inflammation (CRP, AGP, IL-6) and growth hormone-IGF axis (IGF-1, IGFBP3) in infant plasma at 6 weeks and 3, 6, 12 and 18 months, and in paired maternal-infant plasma at birth. Adjusted mean differences between biomarkers were estimated using regression models. Multivariate odds ratios of stunting were estimated by logistic regression. Results At birth, cases were shorter (median (IQR) HAZ −1.00 (−1.53, −0.08) vs 0.03 (−0.57, 0.62,); P
| Reference Key |
prendergast2014plosstunting
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Andrew J. Prendergast;Sandra Rukobo;Bernard Chasekwa;Kuda Mutasa;Robert Ntozini;Mduduzi N. N. Mbuya;Andrew Jones;Lawrence H. Moulton;Rebecca J. Stoltzfus;Jean H. Humphrey; |
| Journal | PloS one |
| Year | 2014 |
| DOI | 10.1371/journal.pone.0086928 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.