Continuous subcutaneous infusion of growth hormone (CSIGH) in GH deficiency
Clicks: 224
ID: 116816
1970
In contrast to the sustained acceleration of growth observed in pituitary hypersecretion in GH, full catch-up growth is rarely attained in GH deficiency with conventional GH Rx (0.1 U/kg IM 3x/wk). Since circulating GH levels are very low for all but 24-30 hr per wk during conventional Rx, we examined the feasibility and metabolic effects of CSIGH using a small infusion pump. Somatomedin-C (SM-C), oral glucose tolerance (GT) and free fatty acids were determined in 7 untreated deficient children before and after 85 hrs of CSIGH (2.1 μU/kg/hr ≃ 0.3 U/kg/wk). CSIGH maintained serum GH at 3-9 ng/ml and produced a modest increase in fasting (0 min) G and I. Glucose tolerance was impaired despite 2-fold higher I levels (*p
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| Authors | J Gertner;S Page;W Tamborlane;J Gertner;S Page;W Tamborlane; |
| Journal | Pediatric research |
| Year | 1970 |
| DOI | doi:10.1203/00006450-198112000-00091 |
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