Plazomicin is effective in a non-human primate pneumonic plague model
Clicks: 223
ID: 116966
2016
The efficacy of plazomicin for pneumonic plague was evaluated in a non-human primate model. African Green monkeys challenged with a lethal aerosol of Yersinia pestis [median (range) of 98 (15-331) LD50s] received placebo (n=12) or 'humanized' dose regimens (6.25, 12.5 or 25mg/kg every 24h …
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wm2016bioorganicplazomicin
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| Authors | Mega WM;Doyle-Eisele M;Cass RT;Kostrub CF;Sherwood RL;Metz MA;Cirz RT;; |
| Journal | bioorganic & medicinal chemistry |
| Year | 2016 |
| DOI | DOI not found |
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
Disease Models
animal*
dose-response relationship
drug
chlorocebus aethiops
molecular conformation
plague / drug therapy*
pmid:27614915
doi:10.1016/j.bmc.2016.08.049
william m mega
melanie doyle-eisele
ryan t cirz
sisomicin / analogs & derivatives*
sisomicin / chemistry
sisomicin / therapeutic use
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