immunomodulatory activity and protective effects of polysaccharide from eupatorium adenophorum leaf extract on highly pathogenic h5n1 influenza infection

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ID: 148082
2013
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Abstract
The development of novel broad-spectrum, antiviral agents against H5N1 infection is urgently needed. In this study, we evaluated the immunomodulatory activities and protective effect of Eupatorium adenophorum polysaccharide (EAP) against the highly pathogenic H5N1 subtype influenza virus. EAP treatment significantly increased the production of IL-6, TNF-α, and IFN-γ both in vivo and in vitro as measured by qPCR and ELISA. In a mouse infection model, intranasal administration of EAP at a dose of 25 mg/kg body weight prior to H5N1 viral challenge efficiently inhibited viral replication, decreased lung lesions, and increased survival rate. We further evaluated the innate immune recognition of EAP, as this process is regulated primarily Dectin-1 and mannose receptor (MR). These results indicate that EAP may have immunomodulatory properties and a potential prophylactic effect against H5N1 influenza infection. Our investigation suggests an alternative strategy for the development of novel antiinfluenza agents and benefits of E. adenophorum products.
Reference Key
jin2013evidence-basedimmunomodulatory Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Yi Jin;Yuewei Zhang;Chunyan Wan;Hongjun Wang;Lingyu Hou;Jianyu Chang;Kai Fan;Xiangming Xie
Journal ACS applied materials & interfaces
Year 2013
DOI
10.1155/2013/194976
URL
http://dx.doi.org/10.1155/2013/194976
Keywords
Other systems of medicine

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