effects of 4-nonylphenol on oxidant/antioxidant balance system inducing hepatic steatosis in male rat
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2015
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Abstract
An emerging literature suggests that early life exposure to 4-nonylphenol (4-NP), a widespread endocrine disrupting chemical, may increase the risk of metabolic syndrome. In this study, we investigated the hypothesis that intraperitoneal administration of 4-NP induces hepatic steatosis in rat. 24 male Sprague-Dawley rats were administered with 4-NP (0, 2, 10 and 50 mg/kg b.wt) in corn oil for 30 days. Liver histology, biochemical analysis and gene expression profiling were examined. After treatment, abnormal liver morphology and function were observed in the 4-NP-treated rat, and significant changes in gene expression an indicator of hepatic steatosis and apoptosis were observed compared with controls. Up-regulated genes involved in apoptosis, hepatotoxity and oxidative stress, increased ROS and decrease of antioxidant enzyme were observed in the 4-NP exposed rat. Extensive fatty accumulation in liver section and elevated serum GOT, GPT, LDH and γ-GT were also observed. Incidence and severity of liver steatosis was scored and taken into consideration (steatosis, ballooning and lobular inflammation). Hepatocytes apoptosis could promote NAFLD progression; Fas/FasL, TNF-α and Caspase-9 mRNA activation were important contributing factors to hepatic steatosis. These findings provide the first evidence that 4-NP affects the gene expression related to liver hepatotoxicity, which is correlated with hepatic steatosis.
| Reference Key |
kourouma2015toxicologyeffects
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|---|---|
| Authors | ;Ansoumane Kourouma;Hady Keita;Peng Duan;Chao Quan;Koikoi Kebe Bilivogui;Suqin Qi;Ndjiembi Adjonga Christiane;Aidogie Osamuyimen;Kedi Yang |
| Journal | international journal of systematic and evolutionary microbiology |
| Year | 2015 |
| DOI |
10.1016/j.toxrep.2015.10.006
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| URL | |
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