a novel green synthesis of thalidomide and analogs

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ID: 151515
2017
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Ranked #134 of 215 articles by views in british journal of psychology (london, england : 1953)

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Abstract
Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.
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benjamin2017journala Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ellis Benjamin;Yousef M. Hijji
Journal british journal of psychology (london, england : 1953)
Year 2017
DOI
10.1155/2017/6436185
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