serine protease autotransporters of enterobacteriaceae (spates): biogenesis and function
Clicks: 213
ID: 199611
2010
Serine Protease Autotransporters of Enterobacteriaceae (SPATEs) constitute a large family of proteases secreted by Escherichia coli and Shigella. SPATEs exhibit two distinct proteolytic activities. First, a C-terminal catalytic site triggers an intra-molecular cleavage that releases the N-terminal portion of these proteins in the extracellular medium. Second, the secreted N-terminal domains of SPATEs are themselves proteases; each contains a canonical serine-protease catalytic site. Some of these secreted proteases are toxins, eliciting various effects on mammalian cells. Here, we discuss the biogenesis of SPATEs and their function as toxins.
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dautin2010toxinsserine
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| Authors | ;Nathalie Dautin |
| Journal | matec web of conferences |
| Year | 2010 |
| DOI | 10.3390/toxins2061179 |
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