lobophytones o–t, new biscembranoids and cembranoid from soft coral lobophytum pauciflorum

Clicks: 198
ID: 221750
2010
Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
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Authors ;Wenhan Lin;Pengcheng Yan;Leen van Ofwegen;Zhiwei Deng;Peter Proksch
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2010
DOI 10.3390/md8112848
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