A Novel Co-polymer Based on Hydroxypropyl α-Cyclodextrin Conjugated to Low Molecular Weight Polyethylenimine as an in Vitro Gene Delivery Vector
Clicks: 165
ID: 261592
2008
A novel co-polymer based on 2-hydroxypropyl-α-cyclodextrin cross-linked by low molecular weight polyethylenimine was synthesized as a gene delivery vector. The copolymer could bind and condense DNA tightly. It showed lower cytotoxicity than PEI 25kDa in SK-BR-3 cells. Transfection efficiency was increased over 5.5-fold higher than PEI 25 kDa in SK-BR-3 cells in complete serum medium. It is a potential candidate vector for gene therapy.
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gu2008internationala
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| Authors | Hongliang Huang,Hai Yu,Da Li,Yang Liu,Fenping Shen,Jun Zhou,Qingqing Wang,Jian-Ming Gu;Hongliang Huang;Hai Yu;Da Li;Yang Liu;Fenping Shen;Jun Zhou;Qingqing Wang;Jian-Ming Gu; |
| Journal | International journal of molecular sciences |
| Year | 2008 |
| DOI | 10.3390/ijms9112278 |
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