Bacterial endotoxin sensitizes the immature brain to hypoxic--ischaemic injury

Clicks: 273
ID: 265926
2001
Epidemiological studies show a markedly increased risk of cerebral palsy following the combined exposure of infection and birth asphyxia. However, the underlying mechanisms of this increased vulnerability remain unclear. We have examined the effects of a low dose of bacterial endotoxin on hypoxic--i …
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Authors Eklind S;Mallard C;Leverin AL;Gilland E;Blomgren K;Mattsby-Baltzer I;Hagberg H;;
Journal the european journal of neuroscience
Year 2001
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11285007
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Brain / drug effects* Rats Receptors messenger / metabolism brain / pathology* wistar reverse transcriptase polymerase chain reaction lipopolysaccharides / pharmacology pmid:11285007 doi:10.1046/j.0953-816x.2001.01474.x s eklind c mallard h hagberg newborn / physiology* body temperature / drug effects brain ischemia / mortality brain ischemia / pathology* cerebrovascular circulation / drug effects drosophila proteins* endotoxins / pharmacology* hypoxia / mortality hypoxia / pathology* lipopolysaccharide receptors / genetics membrane glycoproteins / genetics cell surface / genetics toll-like receptor 4 toll-like receptors

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