Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates

Clicks: 286
ID: 268115
2011
Skeletal metastases represent a frequent complication in patients with advanced prostate cancer (PCa) and often require bisphosphonate treatment to limit skeletal-related events. Metastasized PCa cells disturb bone remodeling. Since the WNT signaling pathway regulates bone remodeling and has been im …
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Authors Thiele S;Rauner M;Goettsch C;Rachner TD;Benad P;Fuessel S;Erdmann K;Hamann C;Baretton GB;Wirth MP;Jakob F;Hofbauer LC;;
Journal journal of cellular biochemistry
Year 2011
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=21344486
Keywords
Tumor National Center for Biotechnology Information NCBI NLM MEDLINE gene expression regulation humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't male aged middle aged cell line in vitro techniques enzyme-linked immunosorbent assay blotting western reverse transcriptase polymerase chain reaction wnt proteins / genetics wnt-5a protein neoplastic / drug effects diphosphonates / pharmacology* imidazoles / therapeutic use Intercellular Signaling Peptides and Proteins / genetics wnt proteins / metabolism* Proto-Oncogene Proteins / metabolism intercellular signaling peptides and proteins / metabolism prostatic neoplasms / metabolism* pmid:21344486 doi:10.1002/jcb.23070 sylvia thiele martina rauner lorenz c hofbauer bone density conservation agents / therapeutic use diphosphonates / therapeutic use neoplastic / genetics prostatic neoplasms / drug therapy prostatic neoplasms / genetics proto-oncogene proteins / genetics wnt1 protein / genetics wnt1 protein / metabolism wnt4 protein zoledronic acid

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