Isoelectric point restriction of cerebrospinal fluid and serum IgG antibodies to measles virus polypeptides in multiple sclerosis
Clicks: 159
ID: 268517
1987
Thirty consecutive isoelectric point (pI)-discrete IgG fractions were isolated from multiple sclerosis (MS) cerebrospinal fluid (CSF) and used to immune precipitate measles virus (MV) polypeptides. Most basic fractions were enriched in activity against nucleocapsid protein (NP), and to a lesser extent against hemagglutinin (H) protein; intermediate fractions were enriched in activity against H and fusion (F) proteins; and more anodic pI fractions were almost exclusively enriched in activity against the large (L) protein of MV. In MS there are marked differences between CSF and autologous serum in regard to antibody activity to MV. In contrast, there were similar profiles of antibody response to MV proteins in SSPE CSF and serum.
| Reference Key |
tourtellotte1987journalisoelectric
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Michael J. Walsh,Paul Shapshak,Michael C. Graves,David T. Imagawa,Wallace W. Tourtellotte;Michael J. Walsh;Paul Shapshak;Michael C. Graves;David T. Imagawa;Wallace W. Tourtellotte; |
| Journal | journal of neuroimmunology |
| Year | 1987 |
| DOI | 10.1016/0165-5728(87)90012-9 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.