Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis

Clicks: 276
ID: 268636
2000
In experimental visceral leishmaniasis, in which the tissue macrophage is the target, in vivo responsiveness to conventional chemotherapy (pentavalent antimony [Sb]) requires a T-cell-dependent mechanism. To determine if this mechanism involves gamma interferon (IFN-gamma)-induced activation and/or …
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Authors Murray HW;Delph-Etienne S;;
Journal Infection and immunity
Year 2000
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10603400
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't female male Disease Models Animal P.H.S. Liver / pathology Knockout interferon-gamma / genetics enzyme inhibitors / pharmacology chronic / immunology amphotericin b / therapeutic use Chronic / genetics granulomatous disease leishmaniasis visceral / immunology* pmid:10603400 pmc97133 doi:10.1128/iai.68.1.288-293.2000 h w murray s delph-etienne antimony / therapeutic use antiprotozoal agents / therapeutic use guanidines / pharmacology interferon-gamma / deficiency interferon-gamma / immunology* visceral / drug therapy* visceral / pathology liver / parasitology macrophages / immunology* nitric oxide synthase / antagonists & inhibitors nitric oxide synthase / deficiency nitric oxide synthase / genetics nitric oxide synthase type ii

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