Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage
Clicks: 282
ID: 268767
1994
Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We studied the involvement of these loci in 13 large HNPCC kindreds originating from three different continen …
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m1994americanmismatch
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| Authors | Nyström-Lahti M;Parsons R;Sistonen P;Pylkkänen L;Aaltonen LA;Leach FS;Hamilton SR;Watson P;Bronson E;Fusaro R;; |
| Journal | American journal of human genetics |
| Year | 1994 |
| DOI | DOI not found |
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
adult
female
male
middle aged
P.H.S.
DNA
human
Genetic Markers
mutation
chromosome mapping
chromosomes
pedigree
genetic linkage
pmid:7942843
pmc1918295
m nyström-lahti
r parsons
r fusaro
pair 2*
pair 3*
colorectal neoplasms
hereditary nonpolyposis / blood
hereditary nonpolyposis / genetics*
dna repair / genetics*
satellite / blood
satellite / isolation & purification
lod score
|
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