Catalytic Cyclopropanation by Myoglobin Reconstituted with Iron Porphycene: Acceleration of Catalysis due to Rapid Formation of the Carbene Species

Clicks: 177
ID: 268893
2017
Myoglobin reconstituted with iron porphycene catalyzes the cyclopropanation of styrene with ethyl diazoacetate. Compared to native myoglobin, the reconstituted protein significantly accelerates the catalytic reaction and the kcat/Km value is 26-fold enhanced. Mechanistic studie …
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Authors Oohora K;Meichin H;Zhao L;Wolf MW;Nakayama A;Hasegawa JY;Lehnert N;Hayashi T;;
Journal Journal of the American Chemical Society
Year 2017
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=29148750
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't pmid:29148750 doi:10.1021/jacs.7b10154 koji oohora hiroyuki meichin takashi hayashi

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