Fidaxomicin versus vancomycin for Clostridium difficile infection

Clicks: 244
ID: 269114
2011
The rates of clinical cure after treatment with fidaxomicin were noninferior to those after treatment with vancomycin. Fidaxomicin was associated with a significantly lower rate of recurrence of C. difficile infection associated with non–North American Pulsed Field type 1 strains. (Funded by Optimer …
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Authors Louie TJ;Miller MA;Mullane KM;Weiss K;Lentnek A;Golan Y;Gorbach S;Sears P;Shue YK; ;;
Journal The New England journal of medicine
Year 2011
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21288078
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't adult female male aged middle aged Comparative Study Prospective Studies Clinical Trial Phase III Randomized Controlled Trial Double-Blind Method Multicenter Study anti-bacterial agents / adverse effects microbial sensitivity tests feces / microbiology intention to treat analysis anti-bacterial agents / therapeutic use* anti-bacterial agents / pharmacokinetics secondary prevention enterocolitis vancomycin / adverse effects vancomycin / therapeutic use* investigators=[] affs=[]) pmid:21288078 doi:10.1056/nejmoa0910812 thomas j louie mark a miller collabauthor(name='opt-80-003 clinical study group' aminoglycosides / adverse effects aminoglycosides / pharmacokinetics aminoglycosides / therapeutic use* clostridioides difficile* / classification clostridioides difficile* / drug effects clostridioides difficile* / isolation & purification clostridium infections / drug therapy* pseudomembranous / drug therapy fidaxomicin vancomycin / pharmacokinetics

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