Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis

Clicks: 225
ID: 269202
2008
We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-tar …
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Authors Quezada G;Koshkina NV;Zweidler-McKay P;Zhou Z;Kontoyiannis DP;Kleinerman ES;;
Journal Antimicrobial agents and chemotherapy
Year 2008
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/17984233
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't female Disease Models animal* cyclophosphamide / administration & dosage intranasal immunocompromised host* aspergillosis / microbiology lung diseases immunosuppressive agents / administration & dosage aspergillosis / drug therapy* pmid:17984233 pmc2224773 doi:10.1128/aac.00760-07 gerardo quezada nadezhda v koshkina eugenie s kleinerman aspergillus fumigatus / drug effects* granulocyte-macrophage colony-stimulating factor / administration & dosage* fungal* / drug therapy fungal* / microbiology

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