Regulation of p53 stability by Mdm2

Clicks: 213
ID: 269406
1997
The tumour-suppressor p53 is a short-lived protein that is maintained at low, often undetectable, levels in normal cells. Stabilization of the protein in response to an activating signal, such as DNA damage, results in a rapid rise in p53 levels and subsequent inhibition of cell growth. Tight regula …
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Authors Kubbutat MH;Jones SN;Vousden KH;;
Journal Nature
Year 1997
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9153396
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't P.H.S. Cultured cell line mutation transcription transfection tumor cells nuclear proteins* proteasome endopeptidase complex proto-oncogene proteins / metabolism* proto-oncogene proteins c-mdm2 tumor suppressor protein p53 / metabolism* proto-oncogene proteins / genetics pmid:9153396 doi:10.1038/387299a0 m h kubbutat s n jones k h vousden acetylcysteine / analogs & derivatives acetylcysteine / pharmacology cysteine endopeptidases / metabolism cysteine proteinase inhibitors / pharmacology multienzyme complexes / metabolism tumor suppressor protein p53 / genetics

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