Botulinum neurotoxins: genetic, structural and mechanistic insights - Nature Reviews Microbiology

Clicks: 216
ID: 271640
2014
Botulinum neurotoxins, which are the most powerful known toxins, are produced by toxigenic clostridia and cause persistent paralysis of peripheral nerve terminals by blocking neurotransmitter release. In this Review, Montecucco and colleagues discuss recent structural and molecular insights into the mechanisms of toxin entry into nerve terminals, membrane translocation and neuroparalysis.
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Authors Rossetto, Ornella;Pirazzini, Marco;Montecucco, Cesare;Rossetto, Ornella;Pirazzini, Marco;Montecucco, Cesare;
Journal Nature Reviews Microbiology
Year 2014
DOI doi:10.1038/nrmicro3295
URL
http://dx.doi.org/10.1038/nrmicro3295
Keywords
bacterial pathogenesis bacterial structural biology bacterial toxins

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