Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP

Clicks: 166
ID: 271909
2011
We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P=3.0E-04, odds ratio (OR)=1.60; meta-P for rs3806933=3.1E-03), XBP1 (rs6005863, P=3.6E-04, OR=1.17; meta-P for rs2269577=9.5E-09), and FOXP3 (rs11798415, P=5.8E-04, OR=1.19). Association of GV with CTLA4 (rs12992492, P=5.9E-05, OR=1.20; meta-P for rs231775=1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P=5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.
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Authors Stanca A. Birlea,Ying Jin,Dorothy C. Bennett,Deborah M. Herbstman,Margaret R. Wallace,Wayne T. McCormack,E. Helen Kemp,David J. Gawkrodger,Anthony P. Weetman,Mauro Picardo,Giovanni Leone,Alain Taïeb,Thomas Jouary,Khaled Ezzedine,Nanja van Geel,Jo Lambert,Andreas Overbeck,Pamela R. Fain,Richard A. Spritz;Stanca A. Birlea;Ying Jin;Dorothy C. Bennett;Deborah M. Herbstman;Margaret R. Wallace;Wayne T. McCormack;E. Helen Kemp;David J. Gawkrodger;Anthony P. Weetman;Mauro Picardo;Giovanni Leone;Alain Taïeb;Thomas Jouary;Khaled Ezzedine;Nanja van Geel;Jo Lambert;Andreas Overbeck;Pamela R. Fain;Richard A. Spritz;
Journal journal of investigative dermatology
Year 2011
DOI 10.1038/jid.2010.337
URL
https://sciprofiles.com/publication/view/275d3d79d0b7690b7fcb84861db14357
Keywords
dermatology linkage disequilibrium case control studies transcription factors epidermis dna binding proteins

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