Function and biological roles of the Dickkopf family of Wnt modulators
Clicks: 182
ID: 271927
2006
Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). They encode secreted proteins that typically antagonize Wnt/beta-catenin signaling, by inhibiting the Wnt coreceptors Lrp5 and 6. Additionally, Dkks are h …
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c2006oncogenefunction
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| Authors | Niehrs C;; |
| Journal | Oncogene |
| Year | 2006 |
| DOI | DOI not found |
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| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
conserved sequence
neoplasms / metabolism
biological
signal transduction
wnt proteins / physiology*
cell lineage
xenopus
xenopus proteins / physiology*
wnt proteins / metabolism
pmid:17143291
doi:10.1038/sj.onc.1210054
c niehrs
body patterning
intercellular signaling peptides and proteins / physiology*
ldl-receptor related proteins / metabolism
low density lipoprotein receptor-related protein-6
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