Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition

Clicks: 254
ID: 272238
1999
T cell expression of class II MHC/peptide complexes may be important for maintenance of peripheral self-tolerance, but mechanisms underlying the genesis of class II MHC glycoproteins on T cells are not well resolved. T cell APC (T-APC) used herein were transformed IL-2-dependent clones that constitu …
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Authors Patel DM;Arnold PY;White GA;Nardella JP;Mannie MD;;
Journal Journal of immunology (Baltimore, Md. : 1950)
Year 1999
DOI DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/10553040
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't Rats Sprague-Dawley Antigens cell line Inbred BALB C Receptors adoptive transfer macrophages / metabolism t-lymphocytes / immunology epitopes glycoproteins / immunology membrane proteins / immunology glycoproteins / metabolism macrophages / immunology antigen spleen / cytology inbred bn membrane proteins / metabolism glycoproteins / biosynthesis thymus gland / cytology antigen-presenting cells / metabolism* interferon-gamma / pharmacology pmid:10553040 d m patel p y arnold m d mannie antigen presentation / immunology* antigen-presenting cells / immunology heterophile / immunology heterophile / metabolism cell communication / immunology transformed / transplantation t-lymphocyte / metabolism* histocompatibility antigens class ii / biosynthesis histocompatibility antigens class ii / metabolism* immune tolerance / immunology interphase / immunology lymphocyte activation / immunology mitogens / pharmacology myelin basic protein / immunology peptides / immunology peptides / metabolism* inbred lew t-cell / physiology t-lymphocytes / metabolism* t-lymphocytes / transplantation

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