IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology

Clicks: 237
ID: 273686
2000
To determine the in vivo role of IL-12 in the development of protective immunity in visceral leishmaniasis caused by Leishmania donovani, we examined the course of L. donovani infection in IL-12-deficient C57BL/6 (IL-12-/-) mice. IL-12-/- mice displayed significantly higher parasite burdens in their …
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Authors Satoskar AR;Rodig S;Telford SR;Satoskar AA;Ghosh SK;von Lichtenberg F;David JR;;
Journal european journal of immunology
Year 2000
DOI DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10741399
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't female male P.H.S. Knockout in vitro techniques kinetics spleen / immunology lymphocyte activation interferon-gamma / biosynthesis interleukin-4 / biosynthesis t-lymphocytes / immunology leishmaniasis visceral / immunology* liver / parasitology liver / pathology* interleukin-12 / physiology pmid:10741399 doi:10.1002/1521-4141(200003)30:33.0.co;2-9 a r satoskar s rodig j r david interleukin-12 / deficiency* interleukin-12 / genetics* leishmania donovani* / isolation & purification leishmania donovani* / pathogenicity visceral / parasitology visceral / pathology* liver / immunology* spleen / parasitology spleen / pathology

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