Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry

Clicks: 256
ID: 273975
2005
The bacteria causing diphtheria, whooping cough, cholera and other diseases secrete mono-ADP-ribosylating toxins that modify intracellular proteins. Here, we describe four structures of a catalytically active complex between a fragment of Pseudomonas aeruginosa exotoxin A (ETA) and its protein subst …
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Authors Jørgensen R;Merrill AR;Yates SP;Marquez VE;Schwan AL;Boesen T;Andersen GR;;
Journal Nature
Year 2005
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