Conditional lethality of the diprotic weak bases chloroquine and quinacrine against Cryptococcus neoformans
Clicks: 181
ID: 274655
2000
Chloroquine at 10 microM enhances the activity of macrophages against Cryptococcus neoformans but does not directly inhibit cryptococcal growth. The antifungal activity of higher chloroquine concentrations likely to be found within the acidic cryptococcal phagosome was tested. Concentrations of > …
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| Authors | Harrison TS;Griffin GE;Levitz SM;; |
| Journal | The Journal of infectious diseases |
| Year | 2000 |
| DOI | DOI not found |
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
microbial sensitivity tests
drug combinations
enzyme inhibitors / pharmacology
anti-bacterial agents / pharmacology
cell division / drug effects
antifungal agents / pharmacology*
chloroquine / pharmacology*
t s harrison
s m levitz
macrolides*
pmid:10882608
doi:10.1086/315649
g e griffin
cryptococcus neoformans / drug effects*
cryptococcus neoformans / metabolism
quinacrine / pharmacology*
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