Synthesis of Mono- and Polyazole Hybrids Based on Polyfluoroflavones.
Clicks: 53
ID: 276558
2023
The possibility of functionalization of 2-(polyfluorophenyl)-4-chromen-4-ones, with them having different numbers of fluorine atoms, with 1,2,4-triazole or imidazole under conditions of base-promoted nucleophilic aromatic substitution has been shown A high selectivity of mono-substitution was found with the use of an azole (1.5 equiv.)/NaOBu(1.5 equiv.)/MeCN system. The structural features of fluorinated mono(azolyl)-substituted flavones in crystals were established using XRD analysis. The ability of penta- and tetrafluoroflavones to form persubstituted products with triazole under azole (6 equiv.)/NaOBu(6 equiv.)/DMF conditions was found in contrast to similar transformations with imidazole. On the basis of mono(azolyl)-containing polyfluoroflavones in reactions with triazole and pyrazole, polynuclear hybrid compounds containing various azole fragments were obtained. For poly(pyrazolyl)-substituted flavones, green emission in the solid state under UV-irradiation was found, and for some derivatives, weak fungistatic activity was found.
| Reference Key |
panova2023synthesismolecules
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | Panova, Mariya A;Shcherbakov, Konstantin V;Zhilina, Ekaterina F;Burgart, Yanina V;Saloutin, Victor I; |
| Journal | Molecules (Basel, Switzerland) |
| Year | 2023 |
| DOI | 869 |
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.