BMP4 Expression Following Stem Cells from Human Exfoliated Deciduous and Carbonate Apatite Transplantation on Rattus norvegicus
Clicks: 244
ID: 47793
2018
Background: Alveolar bone defects in children still
have a high incidence. Conventional bone graft
technique that has been used as a defect therapy is still
not effective, so new techniques with tissue engineering
approach are needed. Bone Morphogenetic Protein 4
(BMP4) as one of the indicators of osteogenic
differentiation has not been widely studied, especially
in the transplantation with combination of Stem Cells
from Human Exfoliated Deciduous (SHED) and
carbonate apatite. Aim and Objectives: This research
aimed to determine the expression of BMP4 after
SHED and carbonate apatite transplantation on Rattus
norvegicus. Material and Methods: The combinations
of SHED and carbonate apatite were transplanted on
alveolar bone defects of 4 rats (Rattus norvegicus) as
the treatment groups and another 4 rats were
transplanted with carbonate apatite as the control
groups. After 21 days, staining with Hematoxylin Eosin
(HE) and Immunohistochemistry (IHC) BMP4 was
performed. Results: BMP4 expression in the treatment
groups was significantly higher when compared to the
control groups. Discussion: Carbonate apatite has low
crystallization rate and high osteoconductivity that
produce more osteoblasts and increased BMP4
expression. Conclusion: The transplantation of SHED
and carbonate apatite increased BMP4 expression as an
indicator of osteogenic differentiation in rats.
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Authors | Saskianti, Tania;Yuliartanti, Windy;Ernawati, Diah Savitri;Prahasanti, Chiquita;Suardita, Ketut; |
Journal | journal of krishna institute of medical sciences university |
Year | 2018 |
DOI | DOI not found |
URL | |
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