Modulated growth of nanoparticles. Application for sensing nerve gases.
Clicks: 228
ID: 60732
2009
Hydrolysis of acetylthiocholine mediated by acetylcholine esterase yields the thiol-bearing compound thiocholine. At trace concentrations, thiocholine modulates the growth of Au-Ag nanoparticles on seeding gold nanoparticles in the presence of ascorbic acid. Inhibition of the enzyme by 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide (BW284c51) or by diethyl p-nitrophenyl phosphate (paraoxon) produces lower yields of thiocholine, promoting the catalytic growth of Au-Ag nanoparticles. Here, we describe the development of a simple and sensitive colorimetric assay for the detection of AChE inhibitors.
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virel2009modulatedanalytical
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| Authors | Virel, Ana;Saa, Laura;Pavlov, Valeri; |
| Journal | Analytical chemistry |
| Year | 2009 |
| DOI | 10.1021/ac801949x |
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