Asymmetric synthesis of atropisomeric pyrazole via an enantioselective reaction of azonaphthalene with pyrazolone.
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ID: 64014
2019
The first catalytic asymmetric reaction of azonaphthalene with pyrazolone has been established. A wide range of axially chiral pyrazole derivatives have been achieved in good yields (68-99%) with excellent enantioselectivities (83-98% ee) by utilizing chiral phosphoric acid as a catalyst. This strategy provides an efficient and facile approach for the construction of axially chiral pyrazole derivatives. Theoretical calculations were carried out to elucidate the origins of enantioselectivity.
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| Authors | Yuan, Huijun;Li, Yao;Zhao, Hanhui;Yang, Zhihong;Li, Xin;Li, Wenjun; |
| Journal | Chemical communications (Cambridge, England) |
| Year | 2019 |
| DOI | 10.1039/c9cc06360a |
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