NHC-Catalyzed Asymmetric Formal [4 + 2] Annulation To Construct Spirocyclohexane Pyrazolone Skeletons.
Clicks: 217
ID: 64662
2019
A chiral N-heterocyclic carbene (NHC)-catalyzed [4 + 2] annulation of γ-chloroenals and α-arylidene pyrazolinones was developed in the absence of expensive oxidants. The reaction proceeds smoothly via a vinyl enolate intermediate to afford spirocyclohexane pyrazolones in moderate to good yield (up to 86%) with high diastereoselectivities (up to 15:1 ) and excellent enantioselectivities (up to >99% ).
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zhao2019nhccatalyzedorganic
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| Authors | Zhao, Chengtao;Shi, Kuangxi;He, Gao;Gu, Qingxiu;Ru, Zhenyuan;Yang, Limin;Zhong, Guofu; |
| Journal | Organic letters |
| Year | 2019 |
| DOI | 10.1021/acs.orglett.9b02927 |
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