Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes.
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ID: 64663
2019
A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15, chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15, respectively.
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| Authors | Lu, Jian;Luo, Ling-Shan;Sha, Feng;Li, Qiong;Wu, Xin-Yan; |
| Journal | Chemical communications (Cambridge, England) |
| Year | 2019 |
| DOI | 10.1039/c9cc05252f |
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