Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity.
Clicks: 300
ID: 69953
2020
Starting from easy accessible pyrazoletetrahydropyran acetals, a series of new pyrazolone spirocyclohexadienone derivatives were synthesized and assayed for antitumor activity. Compound 10s was identified to possess good antitumor activity. It could induce MDA-MB-231 cancer cell apoptosis in a concentration dependent manner and arrest the cell cycle progression mainly at the G1 phase.
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wang2020discoverybioorganic
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| Authors | Wang, Lei;Yang, Zixuan;Ni, Tianyu;Shi, Wencai;Guo, Yunbo;Li, Keliang;Shi, Anzhe;Wu, Shanchao;Sheng, Chunquan; |
| Journal | Bioorganic & medicinal chemistry letters |
| Year | 2020 |
| DOI | S0960-894X(19)30612-2 |
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