Total synthesis of (+)-lepadin B: stereoselective synthesis of nonracemic polysubstituted hydroquinolines using an RC-ROM process.

Barbe, Guillaume; Charette, André B

Total synthesis of (+)-lepadin B: stereoselective synthesis of nonracemic polysubstituted hydroquinolines using an RC-ROM process.

Clicks: 408

ID: 74079

2008

This communication describes a new tandem metathesis reaction for which an RC-ROM mechanism was experimentally supported. This process was successfully applied to the synthesis of cis-fused polyhydroquinolines enabling a short stereoselective total synthesis of ent-lepadin B.

Reference Key	barbe2008totaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors	Barbe, Guillaume;Charette, André B;
Journal	Journal of the American Chemical Society
Year	2008
DOI	10.1021/ja8068215
URL	https://doi.org/10.1021/ja8068215
Keywords	Antimicrobial activity multicomponent reaction antimalarial activity 5-imidazopyrazole incorporated polyhydroquinolines antituberculosis activity

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