Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review.

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2013
Lipid-polymer hybrid nanoparticles (LPNs) are core-shell nanoparticle structures comprising polymer cores and lipid/lipid-PEG shells, which exhibit complementary characteristics of both polymeric nanoparticles and liposomes, particularly in terms of their physical stability and biocompatibility. Significantly, the LPNs have recently been demonstrated to exhibit superior in vivo cellular delivery efficacy compared to that obtained from polymeric nanoparticles and liposomes. Since their inception, the LPNs have advanced significantly in terms of their preparation strategy and scope of applications. Their preparation strategy has undergone a shift from the conceptually simple two-step method, involving preformed polymeric nanoparticles and lipid vesicles, to the more principally complex, yet easier to perform, one-step method, relying on simultaneous self-assembly of the lipid and polymer, which has resulted in better products and higher production throughput. The scope of LPNs' applications has also been extended beyond single drug delivery for anticancer therapy, to include combinatorial and active targeted drug deliveries, and deliveries of genetic materials, vaccines, and diagnostic imaging agents. This review details the current state of development for the LPNs preparation and applications from which we identify future research works needed to bring the LPNs closer to its clinical realization.
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hadinoto2013lipidpolymereuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hadinoto, Kunn;Sundaresan, Ajitha;Cheow, Wean Sin;
Journal european journal of pharmaceutics and biopharmaceutics : official journal of arbeitsgemeinschaft fur pharmazeutische verfahrenstechnik ev
Year 2013
DOI 10.1016/j.ejpb.2013.07.002
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Keywords
Magnetic resonance imaging CT MRI peg drug delivery quantum dots folic acid dox liposomes paclitaxel plga doxorubicin epr computed tomography gene delivery pla cholesterol transferrin tpgs docetaxel pc pet psma hybrid nanoparticles gfp pei dimethyl sulfoxide polyethylene glycol pbs dmso sirna red blood cells pva mrna combretastatin lipid polymer tnf small interfering rna tumor necrosis factor poly(vinyl alcohol) 1,2-dilauroyl-sn-glycero-3-phosphocholine 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol 1,2-dioleoyl-3-trimethylammonium-propane 1,2-dioleoyl-sn-glycero-3-phosphocholine 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-dipalmitoyl-3-trimethylammonium-propane 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-distearoyl-sn-glycero-3-phosphoethanolamine–polyethylene glycol 3β-[n-(n′,n′-dimethylaminoethane)-carbamyl] cholesterol aunc bhem-chol cea cmt com chol core shell nanoparticles dc-chol dcx dlpc dmf dmpe–peg dopc dope dotap dppc dptap dspe–peg dtpa fa fa-oqlcs fap hcl l/p lpns mal-peg-dspe n,n-bis (2-hydroxyethyl)-n-methyl-n-(2-cholesteryloxycarbonyl aminoethyl) ammonium bromide pbae pcx pdi peg-oqlcs peg–pe pfbt print particle replication in non-wetting templates qd rbc re reynolds number tf camptothecin carcinoembryonic antigen d-α-tocopherol peg 1000 succinate diethylene-triamine-pentaacetate dimethyl formamide enhanced permeability and retention fibroblast activation protein folic acid conjugated octadecyl-quaternized lysine modified chitosan gold nanocrystals green fluorescent protein hydrogen chloride lipid polymer nanoparticles lipid to polymer mpeg–dspe mpeg–pla maleimide-terminated polyethylene glycol 1,2-distearoyl-sn-glycero-3-phosphoethanolamine messenger rna methoxy polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine methoxy polyethylene glycol–poly(lactic acid) o/w oil-in-water phosphate buffer saline phosphatidylcholine poly [(9,9-dioctylfluorenyl-2,7-diyl)-co-(1,4-benzo-(2,1′,3) thiadiazole)] poly β-amino ester poly(ethylene terephthalate) poly(ethyleneimine) poly(lactic acid) poly(lactic-co-glycolic acid) polydispersity index polyethylene glycol conjugated octadecyl-quarternized lysine modified chitosan polyethylene glycol–phosphoethanolamine prostate specific membrane antigen scfv sctnf single-chain fv fragments single-chain tumor necrosis factor w/o/w water-in-oil-in-water

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