Palladium-Catalyzed Three-Component Tandem Coupling-Carboannulation Reaction Leading to Polysubstituted [60]Fullerene-Fused Cyclopentanes.

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ID: 79084
2020
The first example of transition-metal catalyzed multicomponent carboannulation of [60]fullerene has been developed. [60]Fullerene, 2-(2,3-allenyl)malonates, and (hetero)aryl iodides undergo a Pd(0)-catalyzed tandem coupling-carboannulation process for regioselective access to novel polysubstituted [60]fullerene-fused cyclopentane derivatives with a wide range of substrate scope and high functional group compatibility. A plausible mechanism involving the formation of a fullerene-π-allylpalladium complex with the characteristic of a fullerene cation as a key intermediate has been proposed.
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Authors Liu, Qingfeng;Liu, Tong-Xin;Ma, Jinliang;Zhang, Guisheng;
Journal Organic letters
Year 2020
DOI 10.1021/acs.orglett.9b04321
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Keywords
green manufacturing manufacturing process chinese patent medicine new technology pharmaceutical equipment

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