Vasorelaxant effects of Crataegus pentagyna: Links with arginase inhibition and phenolic profile.

Clicks: 255
ID: 80641
2020
Crataegus leaves, flowers and fruits have been traditionally used to improve blood circulation, numerous preclinical and clinical studies supporting the cardiovascular benefits of Crataegus preparations. In this respect, there is very limited data on Crataegus pentagyna; in addition, the chemical profile of this species is still incompletely elucidated.The objective of this study was to examine the cardiovascular benefits of Crataegus pentagyna Waldst. et Kit. ex Willd. (small-flowered black hawthorn, Rosaceae) extracts (leaf, flower and fruit ethyl acetate extracts) and the underlying mechanisms. We hypothesized that C. pentagyna extracts might exert vasodilatory effects and inhibit arginase activity due, in large part, to their polyphenolic constituents.C. pentagyna extracts induced-relaxation and the mechanisms involved were studied ex vivo in isolated aortic rings from Sprague-Dawley rats. The inhibitory effects on bovine liver arginase I were assessed by an in vitro assay. Metabolite profiling of C. pentagyna extracts was performed and the most endothelium- and nitric oxide synthase-dependent; flower extract additionally reduced Ca entry and, to a lesser extent, Ca release from the sarcoplasmic reticulum. C. pentagyna proved to be an important source of arginase inhibitors with potential benefits in endothelial dysfunction that remains to be explored.
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Authors Bujor, Alexandra;Miron, Anca;Luca, Simon Vlad;Skalicka-Wozniak, Krystyna;Silion, Mihaela;Trifan, Adriana;Girard, Corine;Demougeot, Céline;Totoson, Perle;
Journal Journal of ethnopharmacology
Year 2020
DOI S0378-8741(19)33794-8
URL
Keywords
caffeic acid (pubchem cid: 689043) chlorogenic acid (pubchem cid: 1794427) rutin (pubchem cid: 5280805) vasorelaxation quercetin (pubchem cid: 5280343) polyphenolic compounds aortic rings arginase inhibition citric acid (pubchem cid: 311) crataegus pentagyna waldst. et kit. ex willd. epicatechin (pubchem cid: 1203) neochlorogenic acid (pubchem cid: 5280633) nor-noha, nω-hydroxy-nor-arginine (pubchem cid: 446124)

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