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Keyword Connections - pyrimidine Keywords

Connection Type	Connection
Journals	Organic letters Bioorganic chemistry current pharmaceutical biotechnology Journal of medicinal chemistry ACS omega The New England journal of medicine
Research Groups	No Research Group Connected
Bibliographies	[1] In vitro Biological Estimation of [1,2,3]triazolo[4,5-d]pyrimidine Derivatives as Anti-breast Cancer Agent: DFT, QSAR and Docking Studies. [2] Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN, and Ethers: Regiocontrollable Synthesis of N- and N-Oxyalkylated 1,2,3-Triazoles. [3] Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors. [4] Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma. [5] Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. [6] Corrigendum to "The modulating effect of lipid bilayer/p-coumaric acid interactions on electrical properties of model lipid membranes and human glioblastoma cells" [Bioorg. Chem. 92 (2019) 103242]. [7] synthesis and evaluation of curcuminoid analogues as antioxidant and antibacterial agents [8] crystal structure of (e)-13-(pyrimidin-5-yl)parthenolide [9] synthesis and biological activity of 4-(4,6-disubstituted-pyrimidin-2-yloxy)phenoxy acetates [10] Preliminary study on antioxidant properties, phenolic contents, and effects of Aesculus hippocastanum (horse chestnut) seed shell extract on in vitro cyclobutane pyrimidine dimer repair [11] Synthesis and characterization of novel 2, 2'-bipyrimidine fluorescent derivative for protein binding [12] Synthesis, Characterization, Antimicrobial Activity and Anticancer of some new pyrazolo[1,5-a]pyrimidines and pyrazolo[5,1-c]1,2,4-triazines. [13] A Validated HPLC-MS/MS Assay for 14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] Mutilin in Biological Samples and Its Pharmacokinetic, Distribution and Excretion via Urine and Feces in Rats [14] Preparation of poly(2,4,6-triaminopyrimidine-TMC)/P84 composite nanofiltration membrane with enhanced chlorine resistance and solvent resistance [15] Novel Brönsted Acidic Ionic Liquids Confined in UiO-66 Nanocages for the Synthesis of Dihydropyrido[2,3-]Pyrimidine Derivatives under Solvent-Free Conditions. [16] Synergistic catalytic effect between ultrasound waves and pyrimidine-2,4-diamine-functionalized magnetic nanoparticles: Applied for synthesis of 1,4-dihydropyridine pharmaceutical derivatives. [17] Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors [18] Graph Theoretical Analysis, Insilico Modeling and Formulation of Pyrimidine Nanoparticles as p38α MAP Kinases inhibitors: A Quantitative Proteomics Approach. [19] Facile water promoted synthesis of 1,2,3-triazolyl dihydropyrimidine-2-thione hybrids - highly potent antibacterial agents. [20] In vitro Biological Estimation of [1,2,3]triazolo[4,5-d]pyrimidine Derivatives as Anti-breast Cancer Agent: DFT, QSAR and Docking Studies. [21] Annellation of Triazole and Tetrazole Systems onto Pyrrolo[2,3-d]pyrimidines: Synthesis of Tetrazolo[1,5-c]-pyrrolo[3,2-e]-pyrimidines and Triazolo[1,5-c]pyrrolo-[3,2-e]pyrimidines as Potential Antibacterial Agents [22] Enhancement of nonlinear optical and thermal properties of polyurethanes by modifying the chromophores with fused heterocyclic and pyrimidine rings [23] Pyranopyrimidine–Triazole Hybrid Molecules [24] Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents. [25] Synthesis, characterization and cytotoxicity studies of 1,2,3-triazoles and 1,2,4-triazolo [1,5-a] pyrimidines in human breast cancer cells [26] Novel pyrimidine-2,4-dione–1,2,3-triazole and furo[2,3-d]pyrimidine-2-one–1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation [27] <b>Synthesis, screening and QSAR studies of 3-benzoyl-2-oxo/thioxo-1,2,3,4-tetrahydro-pyrimidine analogues as antibacterial agents</b> [28] Synthesis and anti-H5N1 virus activity of triazole- and oxadiazole-pyrimidine hybrids and their nucleoside analogs. [29] Synthesis and anticancer activity of some pyrido[2,3-]pyrimidine derivatives as apoptosis inducers and cyclin-dependent kinase inhibitors. [30] Synthesis of Some Polysubstituted Nicotinonitriles and Derived Pyrido[2,3-d]pyrimidines as In Vitro Cytotoxic and Antimicrobial Candidates [31] Corrigendum to “Design, synthesis and evaluation of hybrid of tetrahydrocarbazole with 2,4-diaminopyrimidine scaffold as antibacterial agents” [Eur. J. Med. Chem. 162 (162) (2019) 203–211](S022352341830970X)(10.1016/j.ejmech.2018.11.016) [32] Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors [33] Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease [34] Convenient synthesis of azolopyrimidine, azolotriazine, azinobenzimidazole and 1,3,4-thiadiazole derivatives [35] The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines. [36] Synthesis and Antimicrobial Evaluation of Novel Pyrazolopyrimidines Incorporated with Mono- and Diphenylsulfonyl Groups. [37] Design and evaluation of pyrazolopyrimidines as KCNQ channel modulators. [38] Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). [39] A pyrazolopyrimidine based fluorescent probe for the detection of Cu and Ni and its application in living cells. [40] Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors. [41] Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-] pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs. [42] Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines. [43] Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent. [44] Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor. [45] Novel pyrazolopyrimidines: Synthesis, in vitro cytotoxic activity and mechanistic investigation. [46] The application of bioactive pyrazolopyrimidine unit for the construction of fluorescent biomarkers [47] The development of novel compounds against malaria: Quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines [48] A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation [49] Discovery of pyrazolopyrimidine derivatives as potent BTK inhibitors with effective anticancer activity in MCL [50] New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors [51] Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors [52] COX-1/COX-2 inhibition assays and histopathological study of the new designed anti-inflammatory agent with a pyrazolopyrimidine core [53] Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units [54] Synthesis and characterization of new pyrido- and pyrazolopyrimidine derivatives using 2-substituted vinamidinium salts [55] Dual-response detection of Ni<sup>2+</sup> and Cu<sup>2+</sup> ions by a pyrazolopyrimidine-based fluorescent sensor and the application of this sensor in bioimaging [56] Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer’s disease [57] Synthesis of Some Substituted Pyrazolopyrimidine Derivatives: An Environmentally Benign Approach [58] Pharmacokinetics and in Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis [59] Novel potential pyrazolopyrimidine based translocator protein ligands for the evaluation of neuroinflammation with PET [60] Structural basis of pyrazolopyrimidine derivatives as CAMKIIδ kinase inhibitors: insights from 3D QSAR, docking studies and in silico ADMET evaluation [61] Synthesis and anti-Plasmodium falciparum evaluation of novel pyrazolopyrimidine derivatives [62] Discovery of novel pyrrolopyrimidine/pyrazolopyrimidine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors [63] Efficient acid catalytic synthesis of pyrazolopyrimidines from 1H-pyrazol-5-yl-N,N-dimethylformamidines with cyanamide [64] Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors [65] Brønsted Acidic Ionic Liquid-Catalyzed Regioselective Synthesis of Pyrazolopyrimidines and Their Photophysical Properties [66] Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1- Position [67] Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors. [68] Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives [69] Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives [70] Pyrazolo[3,4-d]pyrimidine based scaffold derivatives targeting kinases as anticancer agents [71] Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. [72] Corrigendum to <‘Synthesis and biological evaluation of 2,6-disubstituted-9H-purine, 2,4-disubstitued-thieno[3,2-d]pyrimidine and -7H-pyrrolo[2,3-d] pyrimidine analogues as novel CHK1 inhibitors’ [Eur. J. Med. Chem. 151 (2018) 836–848] (European Journal of Medicinal Chemistry (2018) 151 (836–848), (S0223523418303192), (10.1016/j.ejmech.2018.03.075)) [73] Copper(I) complexes with tri-o-tolylphosphine and heterocyclic thione ligands. Crystal structures of [(pyrimidine-2-thione)(tri-o-tolylphosphine)copper(I) chloride] and [(pyridine-2-thione)(tri-o-tolylphosphine)copper(I) iodide] [74] ChemInform Abstract: BISMUTH(III) COMPLEXES OF 3,4,5,6-TETRAHYDROPYRIMIDINE-2(1H)-THIONE AND BENZIMIDAZOLE-2(3H)-THIONE. CRYSTAL AND MOLECULAR STRUCTURE OF TRICHLOROTRIS(3,4,5,6-TETRAHYDROPYRIMIDINE-2(1H)-THIONE)BISMUTH(III) [75] Synthesis, characterization and modification of functionalized pyrimidine stabilized gold nanoparticles on ITO electrode for the determination of tannic acid [76] Anti-gastric cancer activity of 1,2,3-triazolo[4,5-d]pyrimidine hybrids (1,2,3-TPH): QSAR and molecular docking approaches. [77] Synthesis and Thermochromic Luminescence of Ag(I) Complexes Based on 4,6-Bis(diphenylphosphino)-Pyrimidine [78] synthesis and evaluation of new anti-microbial additive based on pyrimidine derivative incorporated physically into polyurethane varnish for surface coating and into printing ink paste [79] copper(ii) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1h)-ones and thiones [80] synthesis and evaluation of 3-cyano-4-imino-2-methylthio-4h-pyrido[1,2-a]pyrimidine derivatives as potent antioxidant agents [81] synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against bacillus anthracis [82] pyridinium trifluoro acetate mediated synthesis of 3,4-dihydropyrimidin-2(1h)-ones and tetrazolo[1,5-a]pyrimidine-6-carboxylates [83] cardioprotective efficiency study of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antitumor chemotherapy [84] crystal structure of a mixed-ligand silver(i) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine [85] synthesis and antimicrobial activity of pyrimidine salts with chloranilic and picric acids [86] 1-(4-fluorophenyl)-4,4,6-trimethyl-3,4-dihydropyrimidine-2(1h)-thione [87] 5-(2-ethoxy-4-fluorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine [88] an efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1h)-ones/thiones/imines via a lewis base catalyzed biginelli-type reaction under solvent-free conditions [89] synthesis and antimicrobial activity of some derivatives of 5-substituted indole dihydropyrimidines [90] myeloprotective efficiency of combination of pyrimidine and 3-hydroxypyridine derivatives in experimental antineoplastic chemotherapy [91] spectrophotometric determination of 4-hydroxy-2-mercapto-6-methylpyrimidine based on aggregation of colloidal gold nanoparticles [92] investigation of antimicrobial, antioxidant, and dna binding studies of bioactive cu(ii), zn(ii), co(ii), and ni(ii) complexes of pyrimidine derivative schiff base ligand [93] synthesis and biological activity of reversed pyrimidine nucleosides [94] γ-irradiation and characterization of synthesized methoxybenzylpyrimidine formimidate schiff-base and some metal-complex derivatives [95] synthesis of acyclic nucleoside analogues based on 1,2,4-triazolo[1,5-a]pyrimidine-7-ones by one-step vorbrüggen glycosylation [96] crystal structure of methyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate monohydrate [97] crystal structure of catena-poly[[[aqualithium(i)]-μ-pyrimidine-2-carboxylato-κ4n1,o2:n3,o2′] hemihydrate] [98] crystal structure of (s)-5,7-diphenyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine [99] superparamagnetic iron oxide as an efficient catalyst for the one-pot, solvent-free synthesis of 5,5-disubstituted hexahydropyrimidines and their spiro analogues [100] synthesis and biological activity of some 3,4-dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1h)-one derivatives [101] Discovery of -Phenylaminomethylthioacetylpyrimidine-2,4-diones as Protoporphyrinogen IX Oxidase Inhibitors through a Reaction Intermediate Derivation Approach.