Copper-Catalyzed Three-Component Reaction of Alkynes, TMSN, and Ethers: Regiocontrollable Synthesis of N- and N-Oxyalkylated 1,2,3-Triazoles.
Clicks: 283
ID: 50531
2019
A new copper-catalyzed selective synthesis of N- and N-oxyalkylated 1,2,3-triazoles has been developed through a three-component reaction of alkynes, TMSN, and ethers. Through this methodology, a series of N- and N-oxyalkylated 1,2,3-triazoles could be efficiently and regioselectively obtained from simple and readily available starting materials with favorable functional group tolerance.
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bao2019coppercatalyzedorganic
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| Authors | Bao, Pengli;Yue, Huilan;Meng, Na;Zhao, Xiaohui;Li, Jiangsheng;Wei, Wei; |
| Journal | Organic letters |
| Year | 2019 |
| DOI | 10.1021/acs.orglett.9b02295 |
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